Hair Loss Conditions

Endocrine therapy-induced alopecia

Pattern-like thinning or shedding associated with anti-oestrogen or hormone-modifying treatments.

Endocrine therapy-induced alopecia is most often discussed in people treated for hormone-sensitive cancers, especially breast cancer. Medicines such as aromatase inhibitors or selective oestrogen receptor modulators can reduce oestrogenic signalling and may produce female pattern-like thinning. The clinical pattern may overlap with androgenetic alopecia, so diagnosis considers timing, treatment history and scalp examination. Management should be coordinated with the oncology team because cancer treatment safety takes priority over cosmetic hair goals.

References:

Perez et al., Drugs and androgenetic alopecia, JAAD Reviews 2024: https://doi.org/10.1016/j.jdrv.2024.09.004 ; Anastassakis, Androgenetic Alopecia From A to Z, Vol. 2: https://doi.org/10.1007/978-3-031-08057-9

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